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Comprehensive genomic analyses have revealed a distinct tobacco-related mutational signature in liver tumors of smokers, characterized by cytosine-to-adenine base substitutions, dinucleotide alterations, and guanine adduct formation, patterns resembling those observed in lung and head-and-neck cancers [38,39,40]

Tar inhaled by smoking a single cigarette is 22.3 mg compared to 802 mg in a medium size sheesha head (36 times more tar)

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If I tell someone, is it going to come out that I am losing my mind? Even as visions interrupted Smith at work and booze numbed him at home, the Vikings seemed no wiser to his pain